MicroRNA deficient mice with metabolic deficits
Inflammation is traditionally considered a defense response induced by infection or injury. However, inflammation can also be induced by tissue stress and malfunction in the absence of infection or overt tissue damage. Moreover, chronic infections can lead to prolonged inflammatory states that can have devastating consequences for organisms. Notably, chronic inflammation is now considered a key component of highly prevalent disorders such as obesity, atherosclerosis, inflammatory bowel disease or cancer. Thus, understanding the etiology of chronic inflammation in the context of highly prevalent disorders is critical for the development of novel therapeutic approaches.
Thus, the overarching goal of Henao-Mejia Lab is to use novel mouse genetic tools to define the molecular mechanisms of chronic inflammatory disorders. Since it's beginning in May of 2014, we have used the revolutionary CRISPR/Cas9 system to rapidly generate novel genetic tools that allow us to precisely establish the molecular mechanisms involved in the development of chronic inflammatory conditions. In particular, we have used this technology to interrogate the role of non-coding RNAs (lncRNAs, miRNAs) transcribed from regions of the genome associated with the development of inflammatory pathologies.
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