TECHNOLOGY

To accomplish the long-term goals of the laboratory, we will use the CRISPR/Cas9 genome editing system as a fundamental tool to generate innovative genetically engineered mouse models in extremely short periods of time. Using these novel mouse models in combination with state of the art technologies, we aim to decipher the molecular intercations between innate immune pathways, metabolism and the intestinal microbiota.

We employ state of the art core facilities located at the University of Pennsylvania such as germ-free facility, metagenomic next-generation sequencing and bioinformatics platforms to elucidate the impact of host-microbial interactions in health and disease